My understanding is there is still an eternals movie planned; that gives us big bads in Cronos and Galactus; and the fox acquisition gives us Dr. Doom and Magneto as new "loki" if they want.
I don't think the multiverse will mess with this as much as it does Star Wars/Star Trek.
The comics have a long standing tradition of one-offs and "other Earth" stories.
This gives them a chance to do stories that would either be impossible to get away with in the main universe (Marvel Zombies) or which might be to difficult to fit in the overall narrative (House of M).
Also let's them "James Bond" the actors, and do movies like Wolverine Vs. Hulk
I don't think the multiverse will mess with this as much as it does Star Wars/Star Trek.
The comics have a long standing tradition of one-offs and "other Earth" stories.
This gives them a chance to do stories that would either be impossible to get away with in the main universe (Marvel Zombies) or which might be to difficult to fit in the overall narrative (House of M).
Also let's them "James Bond" the actors, and do movies like Wolverine Vs. Hulk