Although it's likely a bad bet, my bet is no, the U-2 was just wasting fuel. There is no confirmation balloon was doing more than collecting weather and climate data.Wonder if U-2 found what it was looking for? (sorry, couldn't resist).
Further, the delayed assertion after it was shot down that the balloon was tracked from launch on a flight path over Guam and Hawaii before change in wind patterns diverted course over CONUS and U-2 sorties over the balloon not being mentioned until balloon was over CONUS make one doubtful the U-2 did nothing more than allow pilot to take selfies and get a definite promote rating on next OPR.
U.S. tracked China spy balloon from launch on Hainan Island along unusual path